PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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TCO-PEG2-amine
0 ImagesCat. No.: HY-141177CAS No.: 2141981-87-3
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Boc-NH-PEG3
0 ImagesSynonyms: PROTAC Linker 10
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Bis-PEG25-NHS ester
0 ImagesBis-PEG25-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG25-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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tert-Butyl 6-formyl-2-azaspiro[3.3]heptane-2-carboxylate
![tert-Butyl 6-formyl-2-azaspiro[3.3]heptane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w056306.gif "Click to View tert-Butyl 6-formyl-2-azaspiro[3.3]heptane-2-carboxylate Product Detail")
0 ImagesCat. No.: HY-W056306CAS No.: 1440960-67-7
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2-(Bromomethyl)-1,3-dioxolane
0 ImagesCat. No.: HY-W040688CAS No.: 4360-63-8
![1'-(tert-Butoxycarbonyl)-[1,4'-bipiperidine]-4-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w053952.gif "Click to View 1'-(tert-Butoxycarbonyl)-[1,4'-bipiperidine]-4-carboxylic acid Product Detail")
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6-((tert-Butoxycarbonyl)amino)spiro[3.3]heptane-2-carboxylic acid
![6-((tert-Butoxycarbonyl)amino)spiro[3.3]heptane-2-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w058501.gif "Click to View 6-((tert-Butoxycarbonyl)amino)spiro[3.3]heptane-2-carboxylic acid Product Detail")
0 ImagesCat. No.: HY-W058501CAS No.: 1087798-38-6
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2-(Aminooxy)ethanol
0 ImagesCat. No.: HY-W010645CAS No.: 3279-95-6
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tert-Butyl 4-(prop-2-yn-1-yl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W076878CAS No.: 301185-41-1
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Methyl 3-aminobicyclo[1.1.1]pentane-1-carboxylate hydrochloride
![Methyl 3-aminobicyclo[1.1.1]pentane-1-carboxylate hydrochloride](https://file.medchemexpress.com/product_pic/hy-w000158.gif "Click to View Methyl 3-aminobicyclo[1.1.1]pentane-1-carboxylate hydrochloride Product Detail")
0 ImagesCat. No.: HY-W000158CAS No.: 676371-65-6
![Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid](https://file.medchemexpress.com/product_pic/hy-w000132.gif "Click to View Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid Product Detail")
![tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w050186.gif "Click to View tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate Product Detail")
